Pre-numbDOTC Blue has been providing relief from pain for 19 years. Apply to desired area for 20-40 minutes, depending upon skin thickness. Keep out of eye and rinse eye thoroughly if any direct contact occurs.  No occlusive dressings near eyes.  For thick skin or electrolysis, apply for 50-60 minutes.  Can use occlusive dressing such as Saran Wrap on areas away from eyes.